110 Chapter 4 Table 4. Number of antibiotic prescriptions per season per group and observed outcome Diagnosis Influenza SARS-CoV-2 Year/season 2017 2018 2019 2020 1st wave 2nd wave Number of patients 4579 8016 4354 1422 1702 6904 Number of contacts with GP practices 4858 9298 4922 1542 2165 8867 Antibiotic prescriptions per total contacts % (n) 25.1 (1221) 27.9 (2595) 29.6 (1458) 20.7 (319) 9.6 (209) 2.7 (238) Penicillins % (n) 13.9 (676) 15.7 (1458) 17.7 (869) 12.6 (194) 6.7 (145) 2.2 (177) Macrolides % (n) 3.0 (147) 3.9 (364) 3.7 (184) 2.5 (38) 1.0 (21) 0.3 (27) Tetracyclines % (n) 8.1 (393) 8.1 (755) 8.1 (397) 5.5 (85) 1.7 (37) 0.3 (30) Other % (n) 0.1 (5) 0.2 (18) 0.1 (8) 0.1 (2) 0.3 (6) 0.1 (4) Observed outcome Hospital admissions % (n) - - - - 7.5 (128) 3.3 (227) Intensive-care admissions % (n) - - - - 1.5 (25) 0.6 (41) Mortality % (n) - - - - 2.1 (36) 1.0 (71) Difference in proportion of antibiotic prescriptions between influenza seasons and SARS-CoV-2 waves 1st wave % (95% CI) 15.5 (13.8-17.2) 18.3 (16.8-19.8) 20.0 (18.2-21.8) 11.1 (8.7-13.5) - - 2nd wave % (95% CI) 22.4 (21.1-23.7) 25.2 (24.2-26.2) 26.9 (25.6-28.2) 18.0 (15.9-20.1) - - SARS-CoV-2: Severe Acute Respiratory Syndrome coronavirus-2. CI: Confidence Interval. GP: General practitioner
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