161 Routine data registries as a basis to analyse and improve the quality of antimicrobial prescription in Primary Care 6 Table 4. Association of determinants with inappropriate antimicrobial prescribing Model 1 OR 95% C.I. Model 2 OR 95% C.I. Model 3 OR 95% C.I. Model 4 OR 95% C.I. Sex (Female reference) 0.66 (0.65-0.67) 0.67 (0.65-0.68) 0.67 (0.65-0.68) 0.67 (0.65-0.68) Age groups 0 – 4 years (reference) 5-14 years 15-44 tears 45-64 years 65-and older 1 1.40 (1.36-1.43) 1.42 (1.38-1.47) 1.76 (1.72-1.79) 1.81 (1.77-1.84) 1 1.11 (1.06-1.16) 1.12 (1.07-1.17) 1.39 (1.33-1.45) 1.48 (1.41-1.54) 1 1.08 (1.03-1.14) 1.10 (1.05-1.15) 1.37 (1.31-1.43) 1.46 (1.39-1.56) 1 1.08 (1.03-1.14) 1.10 (1.05-1.15) 1.37 (1.31-1.43) 1.46 (1.40-1.52) Migration background* Dutch (reference) Moroccan Turkish Surinamese Dutch Caribbean Global South Global North 1 0.90 (0.87-0.92) 1.15 (1.10-1.21) 1.25 (1.18-1.31) 1.24 (1.19-1.30) 0.99 (0.93-1.07) 1.16 (1.11-1.21) 1 0.90 (0.87-0.92) 1.15 (1.10-1.21) 1.25 (1.19-1.31) 1.24 (1.19-1.30) 0.99 (0.92-1.07) 1.16 (1.11-1.21) 1 0.89 (0.87-0.92) 1.16 (1.10-1.22) 1.27 (1.21-1.34) 1.24 (1.18-1.29) 0.99 (0.92-1.06) 1.16 (1.11-1.20) Households with 1 parent (2 parents reference) 1.07 (1.05-1.10) 1.07 (1.05-1.10) 1.08 (1.05-1.11) Household income Low (reference) Middle High 1 0.99 (0.96-1.04) 0.98 (0.94-1.02) 1 1.01 (0.96-1.05) 0.98 (0.94-1.02) 1 1.00 (0.95-1.04) 0.98 (0.93-1.02) Number of comorbidities 0 (reference) 1 2 3 or more 1 1.27 (1.11-1.453) 1.26 (1.10-1.438) 1.15 (1.00-1.328) 1 1.278 (1.12-1.46) 1.265 (1.11-1.45) 1.157 (1.01-1.36) Primary Care practice size Small (reference) Medium Large 1 1.11 (1.08-1.14) 1.03 (1.01-1.05) Day of prescription (Friday reference) 0.96 (0.94-0.98) A multivariable logistic regression analysis was conducted in a chronologic order for 4 models to test for an association of determinants with inappropriate antimicrobial prescribing. Model 1 was the first and in an each new model determinants were added. Bold indicates a statistical significant association with inappropriate antimicrobial prescribing (p<0.05). OR: Odds ratio. CI; Confidence Interval.
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