Martijn Sijbom

17 Introduction 1 how and to what extent the quality of antibiotic allergy registrations can be improved. In a retrospective observational cohort study, described in chapter 6, we used and combined large health care registries for the purpose of evaluation of antimicrobial use in primary care. The aim was to determine the number of appropriate and inappropriate antimicrobial prescriptions in primary care over a period of 10 years, which patient groups and determinants are associated with appropriate antimicrobial prescribing, and the degree to which antimicrobial prescribing in primary care might be improved. Finally, the main results of all studies are summarized and critically appraised in chapter 7, and recommendations on how to incorporate the results of this thesis in AMS interventions are provided.

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