Martijn Sijbom

41 Trends in antibiotic selection pressure generated in primary care and their association with sentinel antibiotic resistance patterns in Europe 2 Item Item number STROBE recommendation Pag STROBE-AMS new items Pag (b) Indicate number of participants with missing data for each variable of interest NA (c) Cohort study—Summarise follow-up time (eg, average and total amount) NA Other analyses 17 Report other analyses performed—eg, analyses of subgroups and interactions, and sensitivity analyses 17.1 Report subgroup analysis by type of patients and type of microorganism, if applicable 9 Discussion Limitations 19 Discuss limitations of the study, taking into account sources of potential bias or imprecision. Discuss both direction and magnitude of any potential bias 19.1 Provide description of sources of selection bias, including infection control measures, audit and confounding 11 Generalisability 21 Discuss the generalisability (external validity) of the study results 21.1 Discuss study setting, type of hospital, local epidemiology for the generalisability 11-12 Other information Funding 22 Give the source of funding, the role of the funders for the present study and, if applicable, for the original study on which the present article is based 13 Bold typeface indicates main variables included in the STROBE tool. STROBE, Strengthening the Reporting of Observational Studies in Epidemiology; STROBE-AMS, STROBE for antimicrobial stewardship. NA: Not applicable

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