45 Trends in antibiotic selection pressure generated in primary care and their association with sentinel antibiotic resistance patterns in Europe 2 Supplement 4. Slope coefficients of plotting antibiotic spectrum index and volume of antibiotic prescriptions against sentinel multidrug resistant microorganisms Combined cumulative ASI in 2020 Combined total DDD / 1000 inhabitants per day in 2020 Slope coefficient (Beta) p-value* Slope coefficient (Beta) p-value* MRSA 0.94 <0.001 0.73 0.004 E. Coli 0.72 0.006 0.56 0.047 S. Pneumoniae 0.91 <0.001 0.74 0.004 * A p-value less than 0.05 was considered clinically significant. MRSA: Methicillin resistant S. Aureus
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