CONTENTS Chapter 1 Introduction 8 Chapter 2 Trends in antibiotic selection pressure generated in primary care and their association with sentinel antibiotic resistance patterns in Europe 20 Chapter 3 Determinants of inappropriate antibiotic prescription in primary care in developed countries with general practitioners as gatekeepers: a systematic review and construction of a framework 46 Chapter 4 Comparing antibiotic prescriptions in primary care between SARS-CoV-2 and influenza: a retrospective observational study 94 Chapter 5 Cues to improve antibiotic-allergy registration: A mixed-method study 114 Chapter 6 Routine data registries as a basis to analyse and improve the quality of antimicrobial prescription in Primary Care 142 Chapter 7 Discussion 184 English summary 204 Nederlandse samenvatting 212 Curriculum vitae 220 Literatuur lijst 222 Nawoord 226
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