Martijn Sijbom

79 Determinants of inappropriate antibiotic prescription in primary care in developed countries with general practitioners as gatekeepers 3 Study authors Publication year Study design Geographical location Research period Study population Definition of inappropriate antibiotic prescription Number of patients/ practices/general practitioners Silverman 2017 Retrospective database cohort Canada 2012 Patients > 65 years with nonbacterial acute upper RTI. Antibiotic prescription for a non-bacterial acute upper RTI 185,014 patients and visits/ 8990 primary care physicians Acute nasopharyngitis (common cold) Acute bronchitis Acute sinusitis Acute laryngitis/tracheitis Singer 2018 Retrospective cohort Canada Acute mild-to-moderate sinusitis (ICD-9 461) Antibiotic prescription for a viral infection as indicated in the disease group 16,742 patients (15,6%)/ 239 GP's Upper respiratory tract infection (ICD-9 465) Bronchitis (ICD-9 466) Acute rhinitis (ICD-9 460) Acute laryngitis and tracheitis (ICD-9 464) Nasopharyngitis (ICD-9 477) Influenza (ICD-9 487/488) Singer 2018 Retrospective cohort Canada 1999-2016 All antibiotic prescriptions Not according to the guidelines 32 clinics/196,923 patients

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