99 Comparing antibiotic prescriptions in primary care between SARS-CoV-2 and influenza 4 Box 2. Symptoms of SARS-CoV-2 (11) • Coughing • Cold • Sore throat • Shortness of breath while resting or during light exertion • Loss of taste or smell • Fever • Sudden fatigue • Diarrhoea • Headache • Conjunctivitis • Muscle- and joint pains Antibiotic prescriptions The Anatomical Therapeutic Chemical Classification System code J01 was used to identify and extract data on oral antibiotic prescriptions from the ELAN registry. Prescriptions were linked with patients with influenza and patients with COVID-19 through the pseudonymised patient numbers following a check that the date of the antibiotic prescription corresponded with the registration date of the ICPC-1 code. If the date of the antibiotic prescription and the registration date did not correspond, the antibiotic prescription was not included. Hospital and intensive care admissions and mortality An adverse course of COVID-19 was defined in the study as a hospital admission, ICU admission, or mortality. Data on this adverse course were extracted from the EMR in the ELAN registry through examination of the free text in the EMR of each patient with COVID-19. Risk factors for an adverse course of COVID-19 Risk factors tested for association with a severe course of COVID-19 were based on the definition by the Dutch National Institute for Public Health and the Environment (Rijksinstituut voor Volksgezondheid en Milieu; RIVM) and outcomes of recent literature reviews on risk factors for an adverse course of COVID-19 (13–15). Included risk factors
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