181 Impact of anastomotic leakage after colorectal cancer surgery on quality of life: A systematic review Table 1. Characteristics of included studies Reference Year Country Study design Study period No. of patients Inclusion criteria Exclusion criteria Aim of the study Arron et al. 2023 The Netherlands Observational cohort study 20102019 1197 Patients ≥ 18 years, diagnosed with stage I-III CRC History of CRC, IBD, hereditary CRC syndromes, nonDutch speaking or diagnosed with a mental condition limiting the ability to fill out questionnaires, non-elective surgery, resection without primary anastomosis or with end stoma reconstruction To assess whether AL is associated with HRQoL at 6 months and 2 years post-diagnosis and whether AL is associated with a clinically relevant decrease in HRQoL at 6 months and 2 years post-diagnosis compared to the time of diagnosis. Ashburn et al. 2013 United States of America Retrospective cohort study 1980 - 2010 864 Restorative resection for rectal cancers for tumors less than 15 cm from the anal verge Patients with IBD, familial adenomatous polyposis, hereditary and non-polyposis colon cancer; patients undergoing nonrestorative resections To evaluate the impact of AL, when intestinal continuity can still be maintained, on bowel function and QoL in patients undergoing rectal cancer resection with low colorectal or colo-anal anastomoses. di Cristofaro et al. 2014 Italy Prospective cohort study 2020 – 2011 116 Patients admitted for elective CRC surgery Emergency surgery, explorative laparotomy, inoperable CRC or recurrence at follow-up To investigate how postoperative complications after surgery for CRC affect patients’ QoL and satisfaction with care. Hain et al. 2016 France Casematched study 2005 – 2014 135 All patients undergoing laparoscopic sphincter saving partial or TME Patients with temporary or permanent stoma, no minimal follow-up of 1 year, no current chemotherapy, and patients who were included in a previous study from the group that evaluated a postoperative program To assess long-term functional outcomes after laparoscopic, sphincter-preserving operative intervention for rectal cancer, according to the type of AL. 9
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