182 Chapter 9 Table 1. Continued Reference Year Country Study design Study period No. of patients Inclusion criteria Exclusion criteria Aim of the study van Kooten et al. 2022 The Netherlands Observational cohort study 1996 - 1999 1207 Clinically resectable adenocarcinoma with an inferior tumour margin below the level of S1/S2 and within 15cm from the anal verge without evidence of distant metastasis Not having filled out the baseline HRQoL questionnaire, deceased within 30 days after surgery To objectify the difference in short- and long-term HRQoL between uncomplicated and complicated postoperative recovery after TME for rectal cancer. Lim et al 2006 United Kingdom Observational cohort study 2000 - 2014 138 All patients undergoing surgical procedures with low rectal anastomosis (<10 cm from the anal verge). NA To evaluate the effect of (sub)clinical AL on QoL and the significance of features seen on water-soluble contrast enemas in prediction of subsequent anastomotic healing. Marinatou et al. 2014 Greece Retrospective casematched study 2007 - 2012 75 Biopsy-proven CRC Age < 18 or > 80, distant metastatic disease at presentation, initially managed on an emergency basis, history of IBD or hereditary cancer To explore the effect of clinically evident AL on HRQoL. McGiffin et al. 2022 Australia Retrospective cross-sectional study 2004 - 2018 224 Patients undergoing minimally invasive proctectomy with a low extra-peritoneal anastomosis and without a temporary diverting ileostomy. Age <18 years and the inability to give consent for survey participation, patients with temporary diverting ileostomy To analyse the timing and management of AL and to evaluate the effect on longterm QoL and functional outcomes using validated instruments.
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