190 Chapter 9 Table 3. Detailed overview of questionnaires and impaired domains if applicable Reference Time of assessment after surgery Questionnaire Significant impaired domains (in favor of non-AL patient) P values Groups compared Arron et al. 6 months EORTC QLQ-C30 Summary score*/** Role function Social function Global QoL* Physical function* Emotional function* p = 0.00 p = 0.00 p = 0.00 p = 0.00 p = 0.01 p = 0.01 AL vs non-AL after colorectal surgery at time of assessment and compared to baseline Multivariable linear regression analysis NS 2 years EORTC QLQ-C30 No significant outcomes / Multivariable linear regression analysis NS Ashburn et al. 6 months and 1 year SF-36 PCS NA p = 0.01 AL vs non-AL after restorative proctectomy at time of assessment (not compared to baseline) SF-36 MCS NA p = 0.007 CGQL Unclear Unclear > 1 year (range 1 – 6 years) SF-36 PCS NA NS SF-36 MCS NA p = 0.02 CGQL Unclear Unclear di Cristofaro et al. 1 month EORTC QLQ-CR29 EORTC QLQ-C30 EORTC IN-PATSAT32 Outcomes of questionnaires not specified for AL patients Patients without complications vs with complications at time of assessment (not compared to baseline) Multivariate analysis for AL: β = 0.42 p < 0.01 Six months EORTC QLQ-CR29 EORTC QLQ-C30 EORTC IN-PATSAT32 Outcomes of questionnaires not specified for AL patients Multivariate analysis for AL: β = 0.52 p = 0.004
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