191 Impact of anastomotic leakage after colorectal cancer surgery on quality of life: A systematic review Table 3. Continued Reference Time of assessment after surgery Questionnaire Significant impaired domains (in favor of non-AL patient) P values Groups compared Hain et al. Variable, at time of the study (Ranging from 1 – 10 years; Mean 46 months ± 26 after restoration of bowel continuity) EORTC QLQ-CR29 Blood and mucus in stool Frequent bowel movements per day Frequent urination per day p = 0.045 p = 0.04 p = 0.03 Symptomatic AL patients vs. non-symptomatic and non-AL patients after rectal surgery at time of assessment (no baseline assessment performed) van Kooten et al. 3, 6, 12, 18 and 24 months RSCL Global health Activity level p < 0.01 p < 0.01 AL vs non-AL after rectal surgery compared to baseline 14 years EORTC QLQ-C30 NA NS EORTC QLQ-CR29 NA NS Lim et al. Variable, at time of the study (Median 26 months; IQR 19-37 months) EORTC QLQ-C30 NA (only global score given) p = 0.03 Clinical leaks without stoma closure compared to subclinical leaks, clinical leaks with stoma closure and non-AL patients after rectal surgery at time of assessment (no baseline assessment performed) 9
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