194 Chapter 9 Table 3. Continued Reference Time of assessment after surgery Questionnaire Significant impaired domains (in favor of non-AL patient) P values Groups compared Westerduin et al. > 1 year (Median of 41 months (IQR 23–71) and 27 months (IQR 16–43) for no AL and AL group respectively) EORTC QLQ-C30 role function social function overall global health fatigue pain p = 0.049 p = 0.006 p = 0.002 p = 0.04 p = 0.002 AL vs non-AL after rectal surgery at time of assessment (no baseline assessment) EORTC QLQ-CR29 body image anxiety abdominal pain buttock pain flatulence fecal incontinence sore skin p = 0.03 p = 0.02 p = 0.03 p = 0.005 p = 0.008 p = 0.03 p = 0.0007 *not clinically relevant; 1Multivariable linear and logistic regression; 2Wilcoxon rank sum tests; 3Mann–Whitney U-test; 4Kruskal–Wallis ANOVA; 5Multivariate analysis; 6Univariate and multivariate logistic regression; 7Wald’s tests using linear mixed-effects model and univariable Poisson regression analysis; 7Paired samples t-test; 8Statistical analysis unclear. EORTC, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core questionnaires; -C30, cancer-specific; -CR29, colorectal-cancer-specific; EQ-VAS, EuroQoL Visual Analogue Scale score; FISI, Fecal Incontinence Severity Index; FIQL, Faecal Incontinence QoL; Gastrointestinal QoL Index; GIQLI, The Gastrointestinal Quality of Life Index; -IN-PATSAT32, patient satisfaction; NA, not applicable; NS, not significant; SF-12, Short-Form-12 health survey; RSCL, Rotterdam Symptom Checklist; QoL, Quality of Life; SF-36, Short-Form 36 questionnaire
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