199 Impact of anastomotic leakage after colorectal cancer surgery on quality of life: A systematic review CONCLUSIONS This systematic review demonstrated that QoL of CRC patients may be compromised after AL up to one year, but assessment and reporting of QoL needs to be standardized to draw clear conclusions. In addition to exploring strategies for preventing and effectively managing AL, it is crucial to investigate long-term sequelae on patients’ QoL in future research. We recommend incorporating a standardized QoL assessment for CRC patients who have experienced AL and integrating this outcome measure into a core outcome set for research focused on AL in the colorectal field. Continuous assessment and monitoring of QoL in patients undergoing CRC resection is essential to better support for patients throughout their recovery. We emphasize the relevance of uniform reporting of AL outcomes to facilitate comparisons of results in future research. To reach this goal, we advise to follow the proposed questionnaires and timepoint as described by the colorectal cancer ICHOM working group 35 and work on a standardized reporting framework for AL-related research within the CoReAL project. CONTRIBUTORS, ACKNOWLEDGEMENTS AND STATEMENTS The authors would like to express their gratitude to Gregor Franssen, who ensured the appropriate search strategy as a professional clinical librarian at Maastricht University. We would also like to thank the CoReAL collaborative to highlight the QoL knowledge gap: Michel Adamina, Alberto Arezzo, Mahdi Al-Taher, Tan Arulampalam, Saba Balvardi, Paul Barach, Himani Bhatt, Marta Botti, Marylise Boutros, David A. Clark, Freek Daams, Jennifer S. Davids, Anse De Sadeleer, Abe Fingerhut, Nader Francis, Zoe Garoufalia, Roel Hompes, Neil H. Hyman, Mehraneh D. Jafari, John T. Jenkins, Audrey C.H.M. Jongen, Deborah S. Keller, Samuel H. Lai, Jérémie H. Lefevre, Bibi Martens, Justin A. Maykel, Jeongyoon Moon, Nariaki Okomoto, Ian Paquette, Gianluca Pellino, Sherief F. Shawki, Benjamin D. Shogan, Chelliah Selvasekar, Simon N.G. Siu Man, Jasper Stijns, Patricia Tejedor, William Tzu-Liang Chen, Christiaan van Der Leij, Steven D. Wexner, Elizabeth Wick, Marina Yiasemidou. This work was partly funded by the American Society of Colon and Rectal Surgeons (ASCRS) Research Foundation Anastomotic Leak Grant. 9
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