239 DNA and RNA alterations associated with colorectal peritoneal metastases: A systematic review Table 1. Continued Reference Year Country Study Design Patient Inclusion Period Reasons for Patient Exclusion No. of Subjects No. of Genes Investigated Aim of the Study Start End Schirripa et al. 47 2020 Italy CH 01/2010 12/2018 - 499 1 Description of the clinicopathologic features and prognosis of KRAS G12C-mutated metastatic CRC. Shelygin et al. 35 2014 Russia CH 11/2012 02/2014 - 58 7 To describe the epithelial–mesenchymal transition in terms of gene expression profile and somatic changes in CRC patients with or without PM. Shirahata et al. 42 2010 Japan CH - - - 52 1 To examine the expression of the MACC1 gene in primary tumors and to evaluate the correlation between the MACC1 expression and the clinicopathological findings. Shirahata et al. 41 2009 Japan CH - - - 48 1 To examine the methylation status of the Vimentin gene in CRC patients and to evaluate the correlation between this status and the clinicopathological findings. Sjo et al. 36 2011 Norway CH 1987 2006 Stage I–III or stage unknown, distant metastases without PM, no surgery or diverting procedures. 57 1 To evaluate the incidence of PM in CRC patients and to compare clinicopathological characteristics, survival and TP53 mutation status in primary tumors. 11
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