242 Chapter 11 Table 2. Characteristics of patients and tissue samples in included studies. Reference Patients’ Specification No. of Patients for Analysis Tissue Samples Tissue Collection Without PM With PM Astrosini et al. 20 Nonpretreated CRC patients. 54 9 Primary tumor tissue Retrospect, archives of pathology department Atreya et al. 43 Cohort of patients with BRAF mutant mCRC was matched 1:2 to patients with BRAF WT mCRC. 75 45 Not specified Not performed, BRAF status was already known Bruzzi et al. 21 Patients with signed informed consent for biological sample collection from the PETACC-8 trial (stage III CRC patients) were included. 1446 38 FFPE tumor tissues Retrospect, archives of pathology department Cheng et al. 22 Patients who underwent surgery for CRC. Stage IV patients are included for genetic analysis. 260 76 Frozen tumor tissue in liquid nitrogen Retrospect, hospital biobank Christensen et al. 44 Patients with mCRC who had received multiple treatment line (irinotecaban and cetiuximab). 405 43 FFPE tumor tissue blocks from primary tumors Not performed, BRAF, RAS and PIK3CA status was already known He et al. 23 Therapy-naïve synchronous mCRC patients at first diagnosis. 168 26 FFPE tumor tissue blocks Retrospect, archives of pathology department Heublein et al. 24 Patients underwent surgical resection and were divided into three groups according to metastases location. 10 13 FFPE tissue from primary tumors Retrospect, archives of pathology department Jacob et al. 25 Patients undergoing surgery. Four groups; patients without metastases, with LM, with PM and with LM and PM. 12 6 FFPE tissue from primary tumors Retrospect, national database and biobank Jacob et al. 26 CRC patients surgically treated and divided in three groups: patients without metastases, with LM and with PM. 12 6 FFPE tissue from primary tumors Retrospect, archives of pathology department Kawazoe et al. 27 CRC patients with histologically confirmed adenocarcinoma and presence of unresectable metastatic disease. 212 52 FFPE cancer specimens (239 primary tumors and 25 metastases) Retrospect, archives of pathology department
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