243 DNA and RNA alterations associated with colorectal peritoneal metastases: A systematic review Table 2. Continued Reference Patients’ Specification No. of Patients for Analysis Tissue Samples Tissue Collection Without PM With PM Lan et al. 28 Patients with stages I–IV CRC who underwent surgery. 1388 104 Surgery tissue samples Retrospect, hospital biobank Lan et al. 29 Patients with stage IV CRC who underwent surgery. 63 32 Surgery tissue samples Retrospect, hospital biobank Lee et al. 30 Small obstructive colorectal cancer group compared to large non-obstructing colorectal cancer group (contrast group). 5 10 FFPE surgical specimens Retrospect, archives of pathology department Nagahara et al. 31 Patients identified as having primary CRC based on the clinicopathologic criteria described by the Japanese Society for Cancer of the Colon and Rectum. 107 6 Frozen tissue specimens in liquid nitrogen from colorectal tumor tissue and paired healthy tissue at least 10 cm distal from primary tumor Retrospect, archives of pathology department Prasanna et al. 45 Patients with proven mCRC who were registered in the included databases. 4755 1212 Unknown Not performed, BRAF and KRAS/RAS status was already known Roberto et al. 46 Patients with right mCRC with known BRAF mutation status. 154 53 Unknown Not performed, BRAF status was already known Sakuraba et al. 32 Patients undergoing surgery for CRC. 33 5 Frozen tumor specimens and corresponding normal tissues Retrospect, archives of pathology department Sasaki et al. 33 Patients with mCRC treated with systemic chemotherapy, combined with or without bevacizumab, cetuximab or panitumumab. 409 117 FFPE tumor samples Retrospect, archives of pathology department Sayagués et al. 34 Caucasian patients diagnosed with CRC who underwent surgical resection of primary tumor tissues. 80 7 Freshly frozen primary tumor tissues Retrospect, archives of pathology department 11
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