247 DNA and RNA alterations associated with colorectal peritoneal metastases: A systematic review Reported Genes Most studies focused on a selected predefined group of genes (Figure 3). Genes that were predominantly studied were RAS (KRAS/NRAS), PIK3CA, TP53, and BRAF. The remaining 13 genes (e.g., androgen receptor (AR), ASXL Transcriptional Regulator 1 (ASXL1), AT-Rich Interaction Domain 1A (ARID1A), NIMA Related Kinase 2 (NEK2), MET Transcriptional Regulator MACC1 (MACC1), Paired Box 5 (PAX5), Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5), Vimentin, Ret Proto-Oncogene (RET), Histone acetyltransferase (Tip60), PKHD1 Ciliary IPT Domain Containing Fibrocystin/Polyductin (PKHD1), Regenerating Family Member 1 Alpha (REG1A), and Kinesin Family Member 18A (Kif18A)) were, except for ARID1A, all separately examined by individual studies (Figure 4). Three studies did a broader comprehensive genomic analysis on the tissue samples. Jacob et al. performed a PanCancer Progression Panel in 2 studies 25, 26 including 770 genes, and Lee et al. used a Comprehensive Cancer Panel covering 409 genes [30]. All details about the reported genes are displayed in Table 3. Figure 3. Distribution of number of genes investigated. Figure 4. Number of studies investigating specific genes. 11
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