249 DNA and RNA alterations associated with colorectal peritoneal metastases: A systematic review Table 3. Continued Reference Level of Testing Name Genes, Molecules or Panel Investigated Type of Analysis Performed Gene or Molecule Name and Mutation or Expression Status (n) No. of Patients with PM (N) and Outcomes (n) No. of Patients without PM (N) and Outcomes (n) MMR Status (MSI/MSS) Findings as Reported by Authors in Studies Heublein et al. 24 miRNA miRNAs RT-PCR N = 10 N = 13 N/A A set of 31 miRNAs was significantly upregulated in the PM group, while 10 miRNAs were repressed as compared to LM. A set of 2 miRNAs was significantly upregulated in the PM group, while 25 were repressed as compared to M0. hsa-miR-31-5p was significantly overexpressed in PM patients (p = 0.002 b,d). hsa-miR-215-5p Induced 17-fold Compared to LM hsa-miR-31-3p Induced 8.9-fold Compared to LM hsa- miR-31-5p Induced 5.4-fold Compared to LM hsa-miR-483-5p Repressed 0.04fold Compared to LM hsa-miR-1226-5p Repressed 0.29fold Compared to LM hsa-miR- 296-5p Repressed 0.32fold Compared to LM hsa-miR-215-5p Induced 3.6-fold Compared to M0 hsa-miR-148a-3p Induced 2.8-fold Compared to M0 Jacob et al. 25 mRNA PanCancer Progression Panel NanoString analysis N = 6 N = 12 N/A In PM patients, 18 genes demonstrated significant different expression rates (p < 0.05 b,d). Not specified - - 11
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