Danique Heuvelings

31 Quality of reporting on anastomotic leaks in colorectal trials: A systematic review Table 1. Characteristics of included studies Author Year Country Study design Number of patients* Number of studies Aim of the study Type of resections included Alekseev et al. 20 2020 Russia RCT 380 N/A To evaluate the usefulness of ICG FA in reducing AL in patients undergoing a stapled colorectal anastomosis. (L)AR with TME, left colectomy Altomare et al. 21 2021 Italy RCT 54 N/A To compare incidence of AL and severity of postop complications in patients undergoing LAR with diverting stoma or LAR with reinforcement of the anastomosis without diverting stoma. LAR with TME Ansari et al. 22 2017 Australia RCT 326 N/A To compare acute adverse events and postoperative complication rates in a randomized trial of short-course versus longcourse preoperative radiotherapy. APR, (L)AR, Hartmann procedures Badawi et al. 23 2015 Saudi Arabia SR 6921 31 To review risk factors for and protective strategies against AL following minimally access surgery for CRC. (L)AR Bakker et al. 24 2017 The Netherlands RCT 402 N/A To evaluate the efficacy of the C-seal device in reducing AL following stapled colorectal anastomoses. All types of colorectal resections with stapled anastomoses Balciscueta et al. 25 2020 Switzerland SR and MA 1267 4 To evaluate the incidence of AL rate following laparoscopic rectal surgery following one vs two stapler firings for rectal transection. AR Bao et al. 26 2022 Italy RCT follow-up 311 N/A To evaluate overall survival, disease-free survival, and local and distant recurrence in patients with AL following LAR. LAR 2

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