339 Summary, general discussion and future perspectives As QoL of AL patients showed an important decrease at six months post-diagnoses and even up to one year, we encourage that QoL should be assessed and reported when talking about leaks. We therefore advise to follow the ICHOM recommendations 65, and use the EORTC QLQ-C30 tool to capture overall QoL and the -CR29 to capture CRC specific outcomes at baseline (prior to surgery), 6 months after surgery, and then annually during follow-up. Ideally, a standardized set of patient-centered outcome measures to inform value-based health care in CRC patients with AL can be developed, in which both the physical and emotional impact mentioned by our participants can be considered. Finally, this thesis also emphasized the importance of preventive strategies for PM after initial colorectal surgery. We revealed greater attention should be given to BRAF-mutated tumors regarding the development of metachronous PM after curative surgery. Future research should focus on validation of this mutation, alternative biomarker research, and minimal invasive preventive strategies, whether it is optimizing drug delivery systems or new innovative approaches. 14
RkJQdWJsaXNoZXIy MTk4NDMw