34 Chapter 2 Table 1. Continued Author Year Country Study design Number of patients* Number of studies Aim of the study Type of resections included Fujii et al. 43 2019 Japan RCT subanalysis 331 N/A To determine if the IMA should be tied at the origin (high tie) or distal to the left colic artery (low tie) in relation to AL. AR Gadan et al. 44 2020 Sweden RCT 232 N/A To investigate the incidence of and risk factors for permanent stoma beyond 5 years following LAR. LAR Guenaga et al. 45 2003 Brazil SR 5805 18 To assess the safety and effectiveness of MBP based on morbidity and mortality following colorectal surgery. LAR Ha et al. 46 2015 Korea SR and MA 1118 6 To evaluate the effectiveness of transanal tube placement to prevent AL after LAR for rectal cancer using a stapling technique. LAR Ha et al. 47 2017 South Korea SR and MA 78434 34 To assess the oncologic outcomes of AL following restorative surgery for CRC All types of colorectal procedures Habeeb et al. 48 2023 Egypt RCT 74 N/A To compare outcomes of open colorectal anastomosis with side-to-end vs end-to-end configuration in non-emergent sigmoid and rectal cancer surgery in adults. (Ultra)LAR Hajibandeh et al. 49 2019 UK MA 436 4 To compare outcomes of temporary loop ileostomy closure during or after adjuvant chemotherapy following rectal cancer resection. LAR He et al. 50 2022 China RCT follow-up 203 N/A To analyze long-term impact of radiation on major LARS and permanent stoma rates. LAR Hüser et al. 51 2008 Germany SR and MA 2729 27 To evaluate the benefit of a defunctioning ileostomy or colostomy after LAR for CRC. LAR
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