Danique Heuvelings

35 Quality of reporting on anastomotic leaks in colorectal trials: A systematic review Table 1. Continued Author Year Country Study design Number of patients* Number of studies Aim of the study Type of resections included Ivanov et al. 52 2011 Serbia RCT 71 N/A To establish if intraoperative air testing may reduce the dehiscence rate of stapled colorectal anastomoses. Sigmoid resection, LAR, Sigmoidostomy diversion, Hartmann procedure Jafari et al. 53 2021 USA RCT 347 N/A To evaluate whether the use of fluorescence angiography to ensure anastomotic perfusion decreases AL after LAR. LAR Karim et al. 54 2020 Switzerland SR and MA 18039 18 To evaluate cancer-specific outcomes after curative rectal cancer surgery comparing AL with no leak. All types of colorectal procedures Kastora et al. 55 2021 UK SR and MA 25395 15 To assess whether NSAIDs, and their subcategories, increase AL in colonic anastomoses and to identify whether this affects specific anastomotic sites. Right hemicolectomy, left hemicolectomy, AR Kelly et al. 56 2014 UK SR and MA 14344 19 To compare short-term and oncological outcomes following CRC resection performed by surgical trainees and expert surgeons. All types of colorectal procedures Kim et al. 57 2022 Korea SR and MA 1431 12 To compare the effects of high versus low IMA ligation in CRC surgery. (L)AR Koedam et al. 58 2022 The Netherlands RCT 1832 N/A To evaluate oncological outcomes with and without AL after CRC surgery. All types of colorectal procedures Lee et al. 59 2018 Australia SR and MA 1418 7 To evaluate the predictive value of cardiopulmonary exercise testing and field walk tests in surgical outcomes after CRC surgery. All types of colorectal procedures 2

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