350 Chapter 15 routine practice is economically advantageous from the hospital payer’s standpoint, leading to cost savings. If future research provides strong evidence on the reduction of leaks by using fluorescence imaging, which has been widely discussed in Chapter 14 (discussion) of this thesis, we believe this immediately results in improved economic status. Future research is necessary to justify the use of laser speckle contrast imaging, but we expect similar results as for ICG-FA. Additionally, part III underscores the potential economic burden associated with diminished QoL, particularly in the initial six months to one year following surgery, which may necessitate additional healthcare resources and support services. These findings highlight the importance of comprehensive preoperative information, effective communication, and peer support in optimizing patient outcomes, potentially reducing healthcare costs associated with postoperative complications and improving overall patient satisfaction and well-being. Addressing specific discussion points and exploring future perspectives, as outlined in Chapter 14, will facilitate the clinical implementation and translation of our research findings. By enabling more accurate risk stratification and development personalized interventions, the research in part IV also intended to lead to cost-effective approaches for managing CRC patients at risk of PM. Investigating the safety and efficacy of an intraperitoneal hydrogel administration on anastomotic healing in a preclinical model, informs potential surgical practice and contributes to the ongoing efforts to develop treatment strategies to improve patient outcomes and minimize postoperative complications. The findings of this animal study have implications for healthcare costs by assessing the potential benefits and risks associated with intraperitoneal hydrogel use in colorectal surgery. Addressing the observed safety issues early in the development process help minimize potential healthcare expenses associated with adverse events and complications. WORLDWIDE COLLABORATION AND SCIENTIFIC IMPACT Over the past two years, our research group has fostered fruitful collaborations with various research teams both in the Netherlands and internationally. Notably, we have actively participated in the CoReAL project, a consensus expert group facilitating the exchange of ideas among clinicians and researchers to gain worldwide evidence and consensus on AL. This international collaboration has enabled the initiation of a standardized reporting framework for colorectal AL. Our systematic review (Chapter 2), consensus paper (Chapter 3), protocol for radiological reporting (Chapter 4) and systematic review on QoL (Chapter 9) and qualitative interview study (Chapter 10) have already demonstrated the power of these combined international efforts. The consensus paper in chapter 3, in which we used a modified Delphi analysis worldwide, engaged numerous esteemed researchers and experts to give their opinions and fostered collaborative discussions to reach consensus on this crucial
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