36 Chapter 2 Table 1. Continued Author Year Country Study design Number of patients* Number of studies Aim of the study Type of resections included Lin et al. 60 2021 China SR and MA 3137 11 To investigate whether intraoperative ICG angiography can reduce the incidence of AL. LAR Lindgren et al. 61 2011 Sweden RCT follow-up 233 N/A To assess the risk for permanent stoma after LAR for rectal cancer. LAR Lu et al. 62 2016 Australia MA 13655 11 To evaluate the best current evidence assessing AL in rectal cancer resections with curative intent and its impact on survival and cancer recurrence. All types of rectal procedures Ma et al. 63 2020 China SR and MA 3480 18 To assess the relationship between AL and long-term oncological outcomes after curative AR for rectal cancer. AR Ma et al. 64 2019 China RCT secondary analysis 125 N/A To quantify the changes in pelvic anatomic features caused by preoperative radiotherapy for CRC on pelvic MRI and evaluate the ability to predict AL. TME Machado et al. 65 2003 Sweden RCT 100 N/A To investigate functional outcomes of pouch vs non-pouch side-to-end anastomosis after standard TME surgery. LAR with TME Mari et al. 66 2019 Italy RCT 214 N/A To compare the incidence of GU dysfunction and evaluate the incidence of AL and oncological outcomes in patients undergoing elective lap LAR + TME with either high or low ligation of the IMA. LAR with TME Matsuda et al. 67 2015 Japan RCT 100 N/A To clarify whether the level of ligation of the IMA in patients with rectal cancer affects defecatory function. AR
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