37 Quality of reporting on anastomotic leaks in colorectal trials: A systematic review Table 1. Continued Author Year Country Study design Number of patients* Number of studies Aim of the study Type of resections included Matthiessen et al. 68 2007 Sweden RCT 234 N/A To assess if there is a difference in the rate of symptomatic AL in patients randomized to fecal deviation. LAR Mcdermott et al. 69 2015 UK/Ireland SR - 451 To evaluate the role of preoperative, intraoperative, and postoperative factors in the development of colorectal AL. All types of colorectal procedures Menahem et al. 70 2017 Germany MA 660 3 To evaluate if drainage of the extraperitoneal anastomosis after rectal surgery impacts the postoperative complication rate. Rectal resections Mhatre et al. 71 2016 SR 20441 - To identify risk factors for AL and identify a standardized diagnostic protocol to reduce delay in diagnosis of AL. All types of colorectal procedures Mrak et al. 72 2016 Austria RCT 166 N/A To determine whether a protective diverting ileostomy reduces the AL rate. LAR Neutzling et al. 73 2012 Brazil SR 1233 9 To compare the safety and effectiveness of stapled and handsewn colorectal anastomosis. The following primary hypothesis was tested: the stapled technique is more effective because it decreases complications. All types of colorectal procedures Oguz et al. 74 2007 Turkey RCT 109 N/A To investigate the effect of L-alanine-Lglutamine on postoperative complication rate and duration of hospitalization in patients operated for CRC. All types of colorectal procedures Okkabaz et al. 75 2017 Turkey RCT 74 N/A To analyze the outcomes of j-pouch and sideto-end anastomosis in rectal cancer patients treated with lap hand-assisted LAR. LAR 2
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