38 Chapter 2 Table 1. Continued Author Year Country Study design Number of patients* Number of studies Aim of the study Type of resections included Pata et al. 76 2009 Belgium SR with a MA and sensitivity analysis 4417 45 To determine whether a defunctioning stoma should be constructed routinely after TME or whether it could be used selectively to ensure patient safety. TME Peeters et al. 77 2005 The Netherlands Retrospective analysis of RCT 924 N/A To identify risk factors for symptomatic AL in patients undergoing TME for rectal cancer. TME Peters et al. 78 2017 The Netherlands RCT post hoc analysis 112 N/A To investigate the relationship between POI and inflammation and AL after CRC resection. All open colorectal resections Podda et al. 79 2020 Italy SR and MA 1120 4 To determine whether prophylactic drainage after colorectal anastomoses confers any advantage in the prevention and management of AL. All types of colorectal procedures Pucciarelli et al. 80 2019 Italy RCT 379 N/A To assess whether colonic J pouch reconstruction after LAR reduces the incidence of AL compared to standard straight colorectal anastomosis. LAR Qi et al. 81 2022 China SR and MA 580 8 To evaluate the predictive value of peritoneal fluid cytokines in the detection of AL following colorectal surgery. All types of colorectal procedures Qu et al. 82 2015 China SR and MA 4580 14 To quantify the clinicopathologic factors predictive for AL in patients undergoing laparoscopic AR for rectal cancer. Laparoscopic AR Ren et al. 83 2021 China RCT 64 N/A To provide a basis for evaluating the safety and effectiveness of laparoscopic TME. Laparoscopic TME Rojas-Machado et al. 84 2016 Spain SR and MA - 68 To develop a new prognostic index to predict the risk of developing AL after CRC surgery. All types of colorectal procedures
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