39 Quality of reporting on anastomotic leaks in colorectal trials: A systematic review Table 1. Continued Author Year Country Study design Number of patients* Number of studies Aim of the study Type of resections included Rolph et al. 85 2004 UK Intervention review 903 3 To assess the effectiveness and safety of a prophylactic drain after elective colorectal anastomosis. All types of colorectal procedures Rutkowski et al. 86 2014 Poland RCT 177 N/A To evaluate the rate of local recurrence and distant recurrence in patients after R0 resection. TME Saber et al. 87 2013 Egypt RCT 156 N/A To evaluate the efficacy of tube cecostomy as an alternative to colostomy in the managing patients with left-sided colonic carcinoma and rectal cancer with respect to postoperative morbidity and mortality and functional outcomes. All left colon or rectal cancer resections Sangiorgio et al. 2021 Italy Intervention review with MA 252 6 To systematically assess the efficacy of parenteral and oral antibiotic prophylaxis compared to parenteral-only prophylaxis for the prevention of SSI in patients undergoing laparoscopic surgery for CRC resection. All types of laparoscopic colorectal resections 88Schardey et al. 89 2020 Germany RCT 80 N/A To study the efficacy of topical antibiotic treatment on the incidence of AL in rectal cancer surgery. (L)AR Selvamani et al. 90 2022 USA SR 3451 12 To examine the need for blood markers that assist in the early diagnosis of AL after surgery. All types of colorectal procedures Senagore et al. 91 2014 US RCT 258 N/A To assess whether the use of a synthetic, bioabsorbable staple line reinforcement material with circular staplers would reduce postoperative AL in patients with a colorectal, coloanal, or ileoanal anastomosis. All types of colorectal procedures 2
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