TABLE OF CONTENTS Chapter 1 Introduction and outline of the thesis 9 Part I Increasing international consensus on current evidence and reporting of anastomotic leaks after colorectal cancer surgery Chapter 2 Quality of reporting on anastomotic leaks in colorectal trials: A systematic review 25 Chapter 3 International Consensus on Reporting Anastomotic Leaks after colorectal cancer surgery: The CoReAL reporting framework 61 Chapter 4 Proposal of a Reporting and Data System for Colorectal Anastomotic Leakage (CAL-RADS): A study protocol for a categorical CT assessment scheme 89 Part II Improving bowel perfusion assessment to reduce the risk of anastomotic leaks Chapter 5 Simultaneous fluorescence imaging of bowel perfusion and ureter delineation using methylene blue: a demonstration in a porcine model 101 Chapter 6 Quantitative analysis of intestinal perfusion with indocyanine green (ICG) and methylene blue (MB) using a single clinically approved fluorescence imaging system: a demonstration in a porcine model 121 Chapter 7 Real-time intestinal perfusion assessment for anastomotic site selection using Laser Speckle Contrast Imaging: verification in a porcine model 137 Chapter 8 Real-time quantification of Laser Speckle Contrast Imaging during intestinal laparoscopic surgery: successful demonstration in a porcine intestinal ischemia model 153 Part III Patients’ perspectives on colorectal anastomotic leaks Chapter 9 Impact of anastomotic leakage after colorectal cancer surgery on quality of life: A systematic review 175 Chapter 10 The patient perspective on colorectal anastomotic leaks: A qualitative study 205 Part IV Prevention of metachronous peritoneal metastases after colorectal cancer surgery Chapter 11 DNA and RNA alterations associated with colorectal peritoneal metastases: A systematic review 229 Chapter 12 Predictive genetic biomarkers for the development of peritoneal metastases in colorectal cancer 275 Chapter 13 Evaluation of the effect of an intraperitoneal cytostatic-loaded supramolecular hydrogel on intestinal anastomotic healing in an animal model 297
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