85 International Consensus on Reporting colorectal Anastomotic Leaks (CoReAL) • What is the effectiveness of postoperative prophylactic ABX versus no ABX on the percentage of AL after colorectal cancer surgery? • What is the effectiveness of NSAID use versus no NSAID use on the percentage of AL after colorectal cancer surgery? • Does the use of laxatives (e.g. movicolon or magnesiumhydroxide) versus no use of laxatives impact the percentage of AL? • What is the effectiveness of an ERAS protocol versus no ERAS on the percentage early detected AL after colorectal cancer surgery? Does early discharge impact severity of AL after colorectal cancer surgery? • What is the safety/feasibility of a minimal invasive approach versus open reintervention for AL after colorectal cancer surgery? • What other approaches/techniques are present in the literature regarding reintervention for AL after colorectal cancer surgery? 4. Postoperative long term topics • What is the oncologic impact of AL versus no AL following colorectal cancer surgery? • What is the impact of AL versus no AL on quality of life after colorectal cancer surgery? • What is the impact of AL versus no AL on the frequency of additional interventions for sequelae after colorectal cancer surgery? • What is the impact of AL versus no AL on healthcare costs after colorectal cancer surgery? • Are early and late leaks different identities? • How should the impact of AL be measured after colorectal cancer surgery? • When should we measure the impact of AL after colorectal cancer surgery? S2. Search strategy • Pubmed: ((((“Colorectal Neoplasms”[MeSH] OR ((“Neoplasms”[MeSH] OR carcinoma*[tiab] OR adenocarcinoma*[tiab] OR neoplas*[tiab] OR tumour*[tiab] OR tumor*[tiab] OR oncolog*[tiab] OR malignan*[tiab] OR cancer*[tiab]) AND (colorectal*[tiab] OR colon[tiab] OR colonic[tiab] OR rectal[tiab] OR rectum[tiab] OR sigmoid*[tiab]))) AND (“Colectomy”[MeSH] OR “Colorectal Surgery”[MeSH] OR “Rectum/surgery”[MeSH] OR “Colon/surgery”[MeSH] OR ((large bowel[tiab] OR colorectal*[tiab] OR colon[tiab] OR rectum[tiab] OR rectal[tiab] OR ileocaecal[tiab] OR caecum[tiab] OR low anterior[tiab]) AND (resection*[tiab] OR surg*[tiab] OR anastomo*[tiab] OR “Anastomosis, Surgical”[MeSH])) OR (colectom*[tiab] OR hemicolectom*[tiab] OR “total mesorectal excision*”[tiab] OR proctocolectom*[tiab] OR “abdominal perineal resection*”[tiab]))) AND (“Anastomotic Leak”[MeSH] OR (anastomo*[tiab] AND (“adverse effects”[Subheading] OR “complications”[Subheading] OR leak*[tiab] OR complication*[tiab] OR defect*[tiab] OR separation*[tiab] OR dehiscence*[tiab] OR breakdown*[tiab] OR abscess*[tiab)))) AND (((systematic review[pt] OR (((systematic review[ti] OR systematic literature review[ti] OR systematic scoping review[ti] OR systematic narrative review[ti] OR systematic qualitative review[ti] OR systematic evidence review[ti] OR systematic quantitative review[ti] OR systematic meta-review[ti] OR systematic critical review[ti] OR systematic mixed studies review[ti] OR systematic mapping review[ti] OR systematic cochrane review[ti] OR systematic search and review[ti] OR systematic integrative review[ti]) NOT comment[pt] NOT (protocol[ti] OR protocols[ti])) NOT MEDLINE [subset]) OR (Cochrane Database Syst Rev[ta] AND review[pt])) OR (“Meta-Analysis”[pt] OR meta analysis[ti])) OR (“Randomized Controlled Trial”[pt] OR “Controlled Clinical Trial”[pt] OR ((random*[tiab] 3
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