I 380

Danique Heuvelings

Chapter 1 Introduction and outline of the thesis 9
Part I Increasing international consensus on current evidence and reporting of anastomotic leaks after colorectal cancer surgery 23
Chapter 2 Quality of reporting on anastomotic leaks in colorectal trials: A systematic review 25
Chapter 3 International Consensus on Reporting Anastomotic Leaks after colorectal cancer surgery: The CoReAL reporting framework 61
Chapter 4 Proposal of a Reporting and Data System for Colorectal Anastomotic Leakage (CAL-RADS): A study protocol for a categorical CT assessment scheme 89
Part II Improving bowel perfusion assessment to reduce the risk of anastomotic leaks 99
Chapter 5 Simultaneous fluorescence imaging of bowel perfusion and ureter delineation using methylene blue: a demonstration in a porcine model 101
Chapter 6 Quantitative analysis of intestinal perfusion with indocyanine green (ICG) and methylene blue (MB) using a single clinically approved fluorescence imaging system: a demonstration in a porcine model 121
Chapter 7 Real-time intestinal perfusion assessment for anastomotic site selection using Laser Speckle Contrast Imaging: verification in a porcine model 137
Chapter 8 Real-time quantification of Laser Speckle Contrast Imaging during intestinal laparoscopic surgery: successful demonstration in a porcine intestinal ischemia model 153
Part III Patients’ perspectives on colorectal anastomotic leaks 173
Chapter 9 Impact of anastomotic leakage after colorectal cancer surgery on quality of life: A systematic review 175
Chapter 10 The patient perspective on colorectal anastomotic leaks: A qualitative study 205
Part IV Prevention of metachronous peritoneal metastases after colorectal cancer surgery 227
Chapter 11 DNA and RNA alterations associated with colorectal peritoneal metastases: A systematic review 229
Chapter 12 Predictive genetic biomarkers for the development of peritoneal metastases in colorectal cancer 275
Chapter 13 Evaluation of the effect of an intraperitoneal cytostatic-loaded supramolecular hydrogel on intestinal anastomotic healing in an animal model 297
Part V Summary, discussion, future perspectives, and impact 317
Chapter 14 Summary, general discussion and future perspectives 319
Chapter 15 Impact paragraph 347
Chapter 16 Dutch summary | Nederlandse samenvatting 355
Part VI Appendices 367
Acknowledgments | Dankwoord 368
Scientific output 374
About the author 376

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