152 CHAPTER 8 SUPPLEMENTARY FILES S1: SEARCH SYNTAX. Search from 1 January 2009 until 10 July 2022, PubMed: (dose*[Title/Abstract] OR dosa*[Title/Abstract] OR dosi*[Title/Abstract]) AND (low[Title/Abstract] OR lower*[Title/Abstract] OR adjust*[Title/Abstract] OR adapt*[Title/Abstract] OR alter*[Title/Abstract] OR modif*[Title/Abstract] OR regulat*[Title/Abstract] OR tailor*[Title/Abstract] OR reduc*[Title/Abstract] OR underdos*[Title/Abstract] OR *recommend*[Title/Abstract] OR inappropria*[Title/ Abstract] OR appropria*[Title/Abstract] OR incorrect*[Title/Abstract] OR correct*[Title/Abstract] OR incongrue*[Title/Abstract] OR congrue*[Title/Abstract] OR discord*[Title/Abstract] OR concord*[Title/Abstract] OR offlabel[Title/Abstract] OR off-label[Title/Abstract] OR (off[Title/Abstract] AND label[Title/Abstract]) OR “Off-Label Use”[Mesh]) AND (dabigatran[Title/Abstract] OR “dabigatran”[Mesh] OR pradaxa[Title/Abstract] OR rivaroxaban[Title/Abstract] OR “rivaroxaban”[Mesh] OR xarelto[Title/Abstract] OR apixaban[Title/Abstract] OR eliquis[Title/Abstract] OR edoxaban[Title/ Abstract] OR lixiana[Title/Abstract] OR NOAC*[Title/Abstract] OR DOAC*[Title/ Abstract] OR ((anticoagul*[Title/Abstract] OR anti-coagul*[Title/Abstract] OR “Anticoagulants”[Mesh]) AND (novel[Title/Abstract] OR new[Title/Abstract] OR direct[Title/Abstract])) OR (non[Title/Abstract] AND ((*vitamin*[Title/Abstract] AND *antagonist*[Title/Abstract]) OR VKA[Title/Abstract]))) Search from 1 January 2009 until 10 July 2022, EMBASE: (dose*:ti,ab OR dosa*:ti,ab OR dosi*:ti,ab) AND (low:ti,ab OR lower*:ti,ab OR adjust*:ti,ab OR adapt*:ti,ab OR alter*:ti,ab OR modif*:ti,ab OR regulat*:ti,ab OR tailor*:ti,ab OR reduc*:ti,ab OR underdos*:ti,ab OR recommend*:ti,ab OR non-recommend*ti,ab OR nonrecommend*ti:ab OR inappropria*:ti,ab OR appropria*:ti,ab OR incorrect*:ti,ab OR correct*:ti,ab OR incongrue*:ti,ab OR congrue*:ti,ab OR discord*:ti,ab OR concord*:ti,ab OR offlabel:ti,ab OR ‘off-label’:ti,ab OR ‘off label’:ti,ab OR ‘off label drug use’/exp) AND (dabigatran:ti,ab OR ‘dabigatran’/exp OR ‘dabigatran etexilate’/exp OR pradaxa:ti,ab OR rivaroxaban:ti,ab OR ‘rivaroxaban’/exp OR xarelto:ti,ab OR apixaban:ti,ab OR ‘apixaban’/exp OR eliquis:ti,ab OR edoxaban:ti,ab OR ‘edoxaban’/exp OR lixiana:ti,ab OR noac*:ti,ab OR DOAC*:ti,ab OR
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