32 CHAPTER 3 with a laboratory confirmed SARS-CoV-2 infection during hospitalisation, were included. Readmission(s) from a single patient were evaluated as a single continuous presentation. Due to only few exclusion criteria, the database gives a reliable reflection of hospitalised COVID-19 patients during the first months of the pandemic, thus before availability of vaccine-induced immunity, and our analyses should therefore be interpreted as generalisable to patients with (largely) naïve immunity against SARSCoV-2. Local ethics approval was obtained in all participating hospitals. Assessment of informed consent was site specific, depending on national regulations, and has been described previously.13 Any researcher can request the data by submitting a proposal as outlined on https://capacity-covid.eu/for-professionals. Data extraction For this study the following variables were extracted: sex, age, medical history (including history of cardiac electrical disorders), body mass index (BMI), medication, physical examination findings, biomarkers, and follow-up data on the development of electrical disorders, cerebrovascular accident (CVA), pulmonary embolism, and mortality during hospitalisation. Electrical disorders were detected either through continuous rhythm monitoring or with (an) electrocardiogram(s) and were diagnosed according to the American College of Cardiology (ACC)/American Heart Association (AHA)/Heart Rhythm Society (HRS) 2006 key data elements and definitions for electrophysiological studies and procedures.14 Types of electrical disorders included AF, AFL, atrial tachycardia, atrioventricular (AV) nodal re-entry tachycardia, non-sustained ventricular tachycardia (nsVT), sustained ventricular tachycardia (sVT), ventricular fibrillation (VF), first degree AV block, second degree AV block, third degree AV block, complete left bundle branch block (LBBB), and complete right bundle branch block (RBBB). Statistical analyses Baseline characteristics of patients with COVID-19 disease are reported for the date of hospital admission. Categorical variables are presented as counts and percentages and numerical variables as means with standard deviations or medians with interquartile ranges (IQR), depending on the distribution. The prevalence of the development of each arrhythmic and conduction disorder during hospitalisation was calculated for the entire follow-up time (i.e. the time from hospital admission to discharge, death or loss to follow-up) and divided into patients without and with a history of that specific arrhythmic or conduction disorder (i.e. new-onset and recurrent, respectively). Only for patients with AF and for patients with AFL, newonset versus recurrent AF and new-onset versus recurrent AFL were defined as having no history of both AF and AFL versus a history of AF and/or AFL.
RkJQdWJsaXNoZXIy MTk4NDMw