38 CHAPTER 3 C. Conduction disorders Recurrent is defined as a history of that specific electrical disorder. Only for patients with atrial fibrillation (AF) and for patients with atrial flutter (AFL) new-onset versus recurrent AF and new-onset versus recurrent AFL were defined as having no history of both AF and AFL versus a history of AF and/or AFL. The number of patients per group is presented on top of the specific bar. In univariable logistic regression analyses, we observed that the development of newonset AF and/or AFL during hospitalisation was associated with increased in-hospital mortality with an unadjusted OR of 1.90 (95% CI 1.52–2.36) (Supplementary File S3). However, in a multivariable model with sex, age, and new-onset AF and/or AFL as covariates to predict in-hospital mortality, there was only an increased significant association between new-onset AF and/or AFL and in-hospital mortality in males aged between 60 and 72 years (see Figure 2). When extending this model with the CHA2DS2VASc score in the 24.3% of patients in whom this score could be calculated (n=1033), the impact of the development of new-onset AF and/or AFL during hospitalisation appeared to be more strongly associated with increased in-hospital mortality: adjusted OR of 3.80 (95% CI 0.03–84.86) instead of 2.16 (95% CI 0.16–14.11) (Supplementary File S4). In the new-onset AF and/or AFL group, 51.7% (n=217) was admitted to the ICU. In 24.0% (n=23) of the patients for which ICU admission date and AF and/or AFL onset date were available (n=96), AF and/or AFL occurred at least 1 day before ICU admission. In the total cohort, 1.0% (n=60) of patients developed a CVA, whereas in patients with new-onset AF and/or AFL this occurred in 1.7% (n=7). DISCUSSION In this multicentre cohort study, we extracted data of 5,782 hospitalised COVID-19 patients from the large international CAPACITY-COVID registry. Of all electrical disorders, AF and/or AFL was observed in 1 in every 8–9 in-hospital COVID-19 patients.
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