81 TRENDS IN PREVALENCE AND ANTITHROMBOTIC PRESCRIPTIONS IN AF S4A: PATIENT CHARACTERISTICS PROBABLY ASSOCIATED WITH A VKA VERSUS A NOAC PRESCRIPTION IN PATIENTS WITH NEW-ONSET ATRIAL FIBRILLATION DIAGNOSED IN 2015. Univariable analyses Variable VKA (n=295) NOAC (n=115) Unadjusted odds ratio (95% CI) Male sex 150 (50.8) 64 (55.7) 0.82 (0.54-1.27) Age in years 77 (69-84) 68 (59-76) 1.07 (1.04-1.09) Age ≥75 years 171 (58.0) 32 (27.8) 3.58 (2.24-5.72) CHA2DS2-VASc score 3 (2-5) 2 (1-3) 1.53 (1.32-1.77) CHA2DS2-VASc score ≥2 259 (87.8) 76 (66.1) 3.69 (2.20-6.21) Heart failure 71 (24.1) 9 (7.8) 3.73 (1.80-7.75) Hypertension 171 (58.0) 47 (40.9) 2.00 (1.29-3.09) Diabetes mellitus 72 (24.4) 18 (15.7) 1.74 (0.99-3.07) CVA or TIA 29 (9.8) 8 (7.0) 1.46 (0.65-3.29) Vascular diseasea 58 (19.7) 14 (12.2) 1.77 (0.94-3.31) Renal impairmentb 94 (31.9) 11 (9.6) 4.42 (2.27-8.62) Dementia 12 (4.1) 4 (3.5) 1.18 (0.37-3.73) Asthma or COPD 58 (19.7) 17 (14.8) 1.41 (0.78-2.54) Malignancyc 41 (13.9) 11 (9.6) 1.53 (0.76-3.08) History of bleedingd 66 (22.4) 15 (13.0) 1.92 (1.05-3.53) Multivariable analysese Variable Adjusted odds ratio (95% CI) Age in years 1.06 (1.04-1.08) Renal impairmentb 2.92 (1.46-5.84) Data are n (%) or median (interquartile range). a Coronary artery disease or peripheral vascular (arterial or venous) disease. b International Classification of Primary Care (ICPC) code U99.01 (renal impairment) or estimated glomerular filtration rate <60 mL/min/1.73 m2. c Five most prevalent malignancies in the Netherlands (apart from skin cancer): breast cancer, prostate cancer, colon cancer, lung cancer, and haematological cancer. d Posttraumatic extradural/subdural/intracerebral haemorrhage, haemoptysis, epistaxis, haematemesis, melaena, haematochezia, haematuria, menorrhagia, postpartum haemorrhage. e Multivariable analyses with stepwise backward elimination (eliminated if p-value ≥0.05) and with age and CHA2DS2-VASc score as continuous instead of dichotomous variables. CI: confidence interval; COPD: chronic obstructive pulmonary disease; CVA: cerebrovascular accident; n: number; NOAC: non-vitamin K antagonist oral anticoagulant; TIA: transient ischemic attack; VKA: vitamin K antagonist. 5
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