83 TRENDS IN PREVALENCE AND ANTITHROMBOTIC PRESCRIPTIONS IN AF S4C: PATIENT CHARACTERISTICS PROBABLY ASSOCIATED WITH A VKA VERSUS A NOAC PRESCRIPTION IN PATIENTS WITH NEW-ONSET ATRIAL FIBRILLATION DIAGNOSED IN 2017. Univariable analyses Variable VKA (n=145) NOAC (n=255) Unadjusted odds ratio (95% CI) Male sex 81 (55.9) 119 (46.7) 1.45 (0.96-2.18) Age in years 79 (69-85) 73 (66-79) 1.04 (1.02-1.06) Age ≥75 years 87 (60.0) 108 (42.4) 2.04 (1.35-3.09) CHA2DS2-VASc score 3 (2-5) 3 (2-4) 1.13 (1.00-1.29) CHA2DS2-VASc score ≥2 126 (86.9) 211 (82.7) 1.38 (0.77-2.47) Heart failure 36 (24.8) 32 (12.5) 2.30 (1.36-3.90) Hypertension 72 (49.7) 145 (56.9) 0.75 (0.50-1.13) Diabetes mellitus 36 (24.8) 50 (19.6) 1.35 (0.83-2.21) CVA or TIA 12 (8.3) 23 (9.0) 0.91 (0.44-1.89) Vascular diseasea 36 (24.8) 37 (14.5) 1.95 (1.17-3.25) Renal impairmentb 38 (26.2) 47 (18.4) 1.57 (0.97-2.56) Dementia 10 (6.9) 4 (1.6) 4.65 (1.43-15.10) Asthma or COPD 26 (17.9) 54 (21.2) 0.81 (0.48-1.37) Malignancyc 15 (10.3) 36 (14.1) 0.70 (0.37-1.33) History of bleedingd 41 (28.3) 43 (16.9) 1.94 (1.19-3.17) Multivariable analysese Variable Adjusted odds ratio (95% CI) Age in years 1.05 (1.02-1.08) CHA2DS2-VASc score 0.75 (0.61-.092) Heart failure 2.57 (1.38-4.79) Vascular diseasea 2.36 (1.30-4.28) Dementia 3.80 (1.11-13.04) History of bleedingd 1.76 (1.05-2.95) Data are n (%) or median (interquartile range). a Coronary artery disease or peripheral vascular (arterial or venous) disease. b International Classification of Primary Care (ICPC) code U99.01 (renal impairment) or estimated glomerular filtration rate <60 mL/min/1.73 m2. c Five most prevalent malignancies in the Netherlands (apart from skin cancer): breast cancer, prostate cancer, colon cancer, lung cancer, and haematological cancer. d Posttraumatic extradural/subdural/intracerebral haemorrhage, haemoptysis, epistaxis, haematemesis, melaena, haematochezia, haematuria, menorrhagia, postpartum haemorrhage. e Multivariable analyses with stepwise backward elimination (eliminated if p-value ≥0.05) and with age and CHA2DS2-VASc score as continuous instead of dichotomous variables. CI: confidence interval; COPD: chronic obstructive pulmonary disease; CVA: cerebrovascular accident; n: number; NOAC: non-vitamin K antagonist oral anticoagulant; TIA: transient ischemic attack; VKA: vitamin K antagonist. 5
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