92 CHAPTER 6 FIGURE 1: FLOWCHART OF THE FRAIL-AF STUDY. CRNM: clinically relevant non-major; eGFR: estimated glomerular filtration rate; INR: international normalised ratio: NOAC: non-vitamin K antagonist oral anticoagulant; VKA: vitamin K antagonist. Baseline data collection Baseline data are collected by means of a patient questionnaire and a questionnaire for the treating physician on disease-specific information. We collect 1) patient characteristics (sex, age and body weight), 2) all 15 items of the GFI questionnaire (see Supplementary file S1),18 3) all clinical items of the CHA 2DS2-VASc rule, a commonly used rule to calculate stroke risk in patients with atrial fibrillation, consisting of the following items: history of (congestive) heart failure, hypertension, age ≥75 years (two points), diabetes, stroke/transient ischaemic attack (TIA)/thromboembolism (two points), vascular disease (e.g. peripheral artery disease or myocardial infarction), age 64–74 years, and female sex, 4) other relevant clinical information (e.g. type and duration of AF, time in therapeutic INR range of the last year, past bleeding and thromboembolic complications, active curative or palliative malignancy), 5) concomitant medication use, 6) eGFR, and 7) 5-level EuroQol 5-dimension (EQ-5D5L) items to measure health-related quality of life.
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