100 Chapter 7 RESULTS Study population A total of 9373 IBBRs were registered in the DBIR between inception and January 2021, of which 6194 were registered during the study period. After exclusion of patients in whom autologous adjunctive procedures were used (latissimus dorsi flap or other flap), 5260 IBBRs. Implant loss within 6 months occurred after 354 reconstructions (6.7%) and the median time to surgical removal of the implant was 42 days (IQR: 21 to 83 days). The total group of 5260 IBBRs was divided into a training cohort consisting of 4208 reconstructions (80%) and a validation cohort consisting of 1052 reconstructions (20%), with an implant loss rate of 7.0% and 5.6%, (P=0.104) respectively. Patient selection and distribution is visualized in a flow-chart in Figure 1. Baseline characteristics were compared between all IBBRs with and without implant loss in the training and validation cohort. The implant loss group within the training cohort showed a significantly higher BMI, a higher ASA classification, more active smokers, less often use of preoperative antibiotics, more often prepectoral implant placement and a higher volume of the permanent implant or TE. The implant loss group within the validation cohort showed a significantly higher rate of nipple preserving procedures. Further baseline comparisons are presented in Table 1. Figure 1. Flowchart of patient selection and distribution of the training cohort and validation cohort
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