74 Chapter 5 Table 4. Risk factors associated with implant loss Univariate and multivariate mixed-effects analysis of risk factors associated with implant loss, resulting in unadjusted and adjusted ORs, confidence intervals, and corresponding p-values (significant values are denoted in italics). Event rate describes the rate of implant loss in breast reconstructions with and without the evaluated risk factor. BMI: Body mass index; OR: Odds ratio; TE: Tissue expander. * Oncological surgeon’s volume (number of mastectomies performed within the study period) Risk factors Group Event rate (%) Unadjusted OR p-value Adjusted OR p-value Obesity BMI < 30 BMI > 30 9.6 23.4 1 2.877 (1.299–6.376) 0.009 1 3.226 (1.208–8.617) 0.020 Breast size ≤ C cup > C cup 8.4 19.3 1 2.600 (1.214–5.566) 0.014 1 3.132 (1.249–7.858) 0.015 Active smoking No Yes 9.5 25.5 1 3.280 (1.498–7.181) 0.003 1 3.935 (1.414–10.950) 0.009 Nipple-preserving procedure No Yes 6.9 18.5 1 3.081 (1.460–6.502) 0.003 1 4.182 (1.596–10.964) 0.004 Reconstruction type TE Prosthesis 8.9 23.3 1 3.130 (1.483–6.610) 0.003 1 2.609 (1.089–6.252) 0.032 Duration of surgery < 140 min > 140 min 7.5 17.4 1 2.320 (1.021–5.271) 0.044 1 1.476 (0.616–3.539) 0.381 Mastectomy specimen weight < 400 gram > 400 gram 6.4 14.6 1 2.526 (1.055–6.047) 0.037 1 1.640 (0.420–6.690) 0.488 Surgeon’s volume* > 50 6.1 1 1 25–50 16.7 2.881 (1.124–7.388) 0.028 3.070 (1.201–7.848) 0.019 < 25 18.9 3.550 (1.237–10.189) 0.019 4.086 (1.397–11.953) 0.010
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