105 Hypertension awareness, treatment, and control in hypertensive CHD patients 5 steps to change their habits in relation to smoking, diet, weight loss or physical activity. Variable Definition Hypertension Patients had BP measurement during interview ≥140/90mmHg (≥140/85mmHg if participants are diabetic); or both being on antihypertensive treatment during interview, and indication of hypertension by a health professional, in medical records, or discharge letter from index event hospitalization. Aware (overall) Patients indicating they were ever told by a health professional that they had raised blood pressure, to be aware of their BP target and of their last measurement (questions below) were considered aware. Awareness: Told by health professional Patients answering “yes” to the question “Have you ever been told by a doctor (or other health professional) that you have high blood pressure?” were considered aware. Awareness: BP target Patients answering “yes” to the question to the question “Are you aware of what your blood pressure target is?” were considered aware. Awareness: own BP level Patients answering “yes” to the question “Are you aware of your latest blood pressure level and what your target is?” were considered aware. Treatment Patients indicating they used medication to lower blood pressure and reported to use any the following anti-hypertensive drugs during the interview were defined as treated: beta-blockers, ACE inhibitors, angiotensin II receptor antagonists, renin inhibitors, calcium channel blockers, diuretics, or other anti-hypertensive drugs. Medication adherence Patients answering “All the time” or “Nearly all the time” to the question “Since the index event how often did you take your medications as the doctor prescribed?” were considered adherent. Hypertension control Patients with BP < 140/90mmHg (140/85mmHg in diabetic patients) during physical examination at patient interview were considered controlled. Data analysis Continuous variables are presented as mean (standard deviation) and categorical variables were presented as the number and percentage of participants. We calculated the proportion of subjects with controlled and uncontrolled hypertension by demographic characteristics, awareness, and treatment variables. Univariable differences were tested with a chi-square test for categorical variables and a t-test for continuous variables. We subsequently fitted mixed effects logistic regression models with a random intercept by country to identify variables potentially associated with hypertension awareness, treatment and control. The models included the covariates sex, age, index event, educational level, number of antihypertensive medications used, medication adherence, BMI, diabetes and LDL ≥1/8mmol/L smoking, physical activity, and undertaking lifestyle changes. The results of the regression analysis are presented as odds ratios (OR) and 95% confidence intervals (95%CI). All analyses were performed with the software R version 4.0 (16). Statistical significance was considered at a two-sided p<0.05. Table 1. Definitions of BP awareness, treatment and control variables.
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