25 Prevalence of secondary prevention medication use in South America 2 Figure 2. Risk of bias results. Prevalence of medication The prevalence of medication for each study as well as the pooled prevalence estimate per medication is displayed in Figures 3-5 and summarized in Table 2. The prevalence of beta-blockers was reported in 53 studies, with a pooled estimate of 73.4% (95%CI 66.8% – 79.1%) (Figure 3). 44 articles reported the prevalence of ACEI/ARB use, with a pooled estimate of 55.8% (95%CI 49.7% – 61.8%) (Figure 3). The overall prevalence of antiplatelet drugs (including aspirin, clopidogrel, and articles that didn’t specify the antiplatelet drug) was retrieved from 51 studies, and the pooled prevalence estimate was 84.6% (95%CI 79.6% – 88.5%) (Figure 4). The prevalence of aspirin specifically was retrieved from 44 studies and their pooled estimate was 85.1% (95%CI 79.7% – 89.3%) (Figure 4). The prevalence of statins was reported in 50 articles and the estimated pooled prevalence was 78.9% (95%CI 71.2% – 84.9%) (Figure 5). Total heterogeneity in the meta-analysis models high, ranging from 97.8% (ACEI/ARBs model) to 99.0% (antiplatelet model). No significant differences were observed in the prevalence of any medication classes between Brazil and other countries.
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