32 Chapter 2 The pooled prevalence estimates of medications and medication classes reported by fewer articles is displayed in supplementary figures 3-5 and summarized in Table 2. This includes antihypertensive drugs (without specification), diuretics, nitrates, antiplatelet drugs (without specification), calcium channel blockers, clopidogrel, dual antiplatelet therapy, lipid-lowering drugs (without specification), and fibrates. Figure 6. Time trends in medication use. Note: Each circle represents a study and the size of the circle is proportional to the number of participants in the study. Guideline compliance From the publications included, 19 articles reported whether the prevalence of medication use was adequate. Half of them reported that medication use was low (59,62,76–78) or insufficient compared to guideline recommendations (2,12,48,61,79). Other articles reported that cardioprotective Guideline compliance From the publications included, 19 articles reported whether the prevalence of medication use was adequate. Half of them reported that medication use was low (59,62,76–78) or insufficient compared to guideline recommendations (2,12,48,61,79). Other articles reported that cardioprotective medication use was adequate or high (32,60,66,67,73,75), or in line with guideline recommendations (38,65,80). Determinants of medication use Determinants reported in publications Variables independently associated with medication use included sex, age, socio-economic status, residency, prevalence of cardiovascular risk factors, diagnosis category of CHD
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