Anna Marzá Florensa

54 Chapter 2 Publication Risk of bias score justification Villalobos, 2013 Single centre, unclear inclusion and exclusion criteria. Vicario, 2005 Pilot study, sample selected from small patient group. Arazi , 2010 Unclear recruitment period and methodology data collection on medication use, single centre. Arantes , 2020 Medication use was an exclusion criteria, single centre. Theme-Filha, 2005 Participation rate field: lack on information on response or participation rate. Barbosa, 2014 Single centre, unclear how data on diagnosis and medication was collected. Taty Zau , 2018 Unclear origin of the study population, number of centres, and unclear methodology to collect medication use data. Stein, 2004 Single centre, no detailed inclusion and exclusion criteria Serrano, 2010 Unclear methodology to diagnose CAD is diagnosed and to measure medication use, unclear inclusion and exclusion criteria, single centre. Santana-Santos, 2014 Single centre, unclear methodology to collect data, low participation rate,. Salvetti, 2008 Unclear methodology to define diagnosis and to collect data on medication use, single centre. Rinaldi, 2013 Unclear Inclusion and exclusion criteria and methodology to collect outcome data Resnik, 2016 Unclear sampling method, limited information on participant's characteristics. Rao, 2017 Unclear origin of the study population, vague inclusion and exclusion criteria, single centre, unclear methodology to collect data on medication use, unclear recruitment period. Prado, 2015 Sample selection not at random, single centre. Piantá, 2015 Single centre, unclear methodology to collect data on participants characteristics. Pesaro, 2012 Another record (Pesaro 2012) provides data on the same study with larger sample size. Pesaro , 2012 Cross-sectional design, single centre, limited information on how participant's characteristics and medication information was collected. Peressoni, 2004 Unclear number of centres, unclear methodology to obtain baseline data. Barbosa, 2019 Unclear methodology for data collection. Blanco , 2016 Unclear methodology for data collection. Blümel, 2003 Single centre, unclear sampling method. Borges, 2010 Single centre, unclear how participants characteristics and medication data was obtained Oliveira, 2004 Cross-sectional design, use of secondary data, single centre. Nogueira, 2010 Single centre, retrospective design, sampling by convenience. Nicolau, 2007 Unclear number of centres and origin of the study population, medication is part of the inclusion criteria, unclear method for data collection of participants characteristics and medication. Neves, 2007 Single centre, unclear methodology to collect data on mediation and demographics, unknown study period. Braga, 2015 Unclear data collection methodology on participant characteristics Burdiat, 2016 Single centre Camargo, 2014 Small subgroup in single centre Castañeda-Amado, 2017 Retrospective design, unclear how participants characteristics data was collected, unclear sampling method. Castello-Simões, 2015 Cross-sectional design, unknown study time or location, unclear how data on medication was obtained. Castillo Costa, 2018 Unknown location, unclear how patient's characteristics data was obtained Castro, 2004 Unknown study time or location, unclear how participants characteristics and medication information was collected. Cardozo GG, 2015 Single centre, no sample size calculation Caruso FR, 2016 Design: cross-sectional design Cruz, 2009 Single centre and no sample size calculation Cruz, 2012 Limited study design information Dantas, 2002 Single centre, no sample size calculation da Luz, 2005 Single centre, retrospective design, unclear patient selection method. Supplementary File 3 C: Reasons for exclusion for articles with a risk of bias score <6.

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