65 Risk factor clustering by sex in the Southern Cone of Latin America 3 Women presented with a higher number of RF than men (OR 1.05, 95% CI 1.02-1.08, Figure 2A and Table 2). 84.9% of women and 81.5% of men presented ≥ 4 RF, and 60.7% of women and 57.1% of men presented ≥ 5 RF. By RF type, the burden of cardiometabolic RF was higher in women (OR 1.17, 95% CI 1.09-1.25) (Figure 2A, Table 2) while that of lifestyle RF was similar in men and women.The most common RF combinations among subjects with ≥ 4 RF were hypertension / dyslipidemia / obesity / unhealthy diet (28.3% of men and 29.6% of women); and hypertension / diabetes / obesity / unhealthy diet (12.5% of men and 14.1% of women) (Table 3). Some combinations were more common in women: dyslipidemia / diabetes / low physical activity (9.8% and 7.1%, p=0.04), and hypertension / diabetes / obesity / low physical activity (8.1% and 5.0%, p=0.01 respectively). Combinations including smoking and excessive alcohol use were more frequent in men: hypertension / dyslipidemia/ unhealthy diet / smoking (10.6% and 7.5%, p=0.00), and hypertension / diabetes / obesity / excessive alcohol consumption (8.5% and 5.8%, p=0.00) (Table 3). Supplementary Table 2 shows the prevalence of all combinations in men and women with at least 4 RF. Women with primary education presented with a higher number of overall (RR 1.08, 95% CI 1.03-1.12) and cardiometabolic RF (RR 1.23, 95% CI 1.13-1.34) compared to men with the same educational level (Figure 2B, Table 2). There were no significant differences in the overall number of RF by sex in participants with secondary education. Results from the subjects with tertiary education showed a lower number of lifestyle RF in women (RR 0.80 0.68-0.93) although this difference was not reflected in significant differences in the total RF number (Figure 2D, Table 2). Those with a high educational attainment presented with a lower burden of RF compared to those with lower educational attainment. The percentages of men and women with 0 to 8 RF, respectively 0 to 4 cardiometabolic or lifestyle RF are detailed in Supplementary Table 1.
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