4. Effects of keloid properties on treatment efficacy 105 Study Keloid properties Treatment groups Results Outcome measure Relevant study characteristics (n = no. keloids) AbdelMeguid et al., 2015 Duration, size A: IL cryosurgery; B: contact cryosurgery - Duration: NS. - Size: smaller keloids had a better response to contact cryosurgery, while size of the keloids did not significantly affect the response to intralesional cryosurgery. Keloid height Duration : ≤ 2 years (n=48), > 2years (n=18). Size: small <1 cm2 (n=41), medium 1-5 cm2 (n=21), large >5 cm2 (n=4). Total no. keloid patients: 33. \Albalat et al., 2022 Duration, skin type A: IL TCA; B: IL verapamil; C: IL 5FU; D: IL PRP - Fitzpatrick skin type and duration: NS. POSAS score Mean duration (months): 4 (n=40), 5 (n=40), 4 (n=40), 5 (n=40). Fitzpatrick skin type: Type 3 (n=109), type 4 (n=45), type 5 (n=6). Total no. keloid patients: 160. AlukoOlokun et al., 2014 Location A: IL TCA; B: excision + radiotherapy - Location: higher cure rate on cheek, forehead, submandibular and lip with TCA compared to the pinna. NS between different locations in excision + radiotherapy group. Keloid height and recurrence Location (TCA group): Pinna (n=13), cheek (n=16), forehead (n=7), submandibular (n=9), lip (n=11). Location (excision + radiotherapy group): Pinna (n=12), cheek (n=13), forehead (n=7), submandibular (n=12), lip (n=9). Total no. keloid patients: 107. Belie et al., 2021 Location A: IL verapamil; B: IL TCA monotherapy - Location: significant decrease in pain and pruritus in keloids located on the head, neck and trunk with TCA, at resp. the 2nd and 3rd visit, whereas the response in the VTG showed a significant reduction in symptoms in both regions at the 4th visit. VAS for pain and pruritis Pain: Head/neck (n=17), Trunk (n=19), Upper limb (n=6), lower limb (n=1). Pruritis: Head/neck (n=19), Trunk (n=20), Upper limb (n=4), lower limb (n=8).
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