5. Needle-free electronically-controlled jet injector treatment with bleomycin is efficacious and well-tolerated in patients with severe keloids: results of a randomized, double-blind, placebo-controlled trial. 124 CI; -3.2, -1.4; p = 0.0022) showed a statistically significant improvement in the bleomycin treated lesions. Similarly, the total POSAS observer score was 41.0 points at baseline, and was reduced with 20% (LSM -8.4; CI -9.8, -6.9) at follow-up, versus a reduction of 4% (LSM -1.6; CI -3.0, -0.1) for those lesions treated with placebo. For the observer POSAS, the parameters thickness (-32%; LSM -2.3; CI -2.8, -1.7; p=0.01), relief (-23%; LSM -1.7; CI -2.2, -1.2; p = 0.01), surface (-42%; LSM -3.2 CI -3.7, -2.7; p< 0.01) and overall opinion (- 21%; LSM -1.5; CI -1.8, -1.2; p < 0.01) were significantly improved at follow-up in the bleomycin treated lesions. The POSAS observer score for pigmentation was 7.7 points at baseline, and was significantly worsened with 7% at follow-up (LSM 0.6; CI 0.2, 1.0; p <0.01). Placebo Bleomycin Week 0 Week 4 Week 8 Week 12 5 mm 5 mm 5 mm 5 mm 5 mm 5 mm 5 mm 5 mm
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