5. Needle-free electronically-controlled jet injector treatment with bleomycin is efficacious and well-tolerated in patients with severe keloids: results of a randomized, double-blind, placebo-controlled trial. 137 Table S2 Analysis results of POSAS observer- and patients scores. Data is presented as LS mean, Δ representing LSM change from baseline, 95% confidence interval and a p-value (Bleomycin-Placebo). Bleomycin Placebo Day 0 Δ Day 29 Δ Day 57 Δ Day 85 Day 0 Δ Day 29 Δ Day 57 Δ Day 85 pvalue Observer scale Vascularity 6.51 6.30 (5.78, 6.81) 6.30 (5.78, 6.81) 5.32 (4.78, 5.85) 6.51 6.30 (5.78, 6.81) 6.15 (5.63, 6.67) 6.22 (5.69, 6.75) 0.11 Observer scale Pigmentation 6.90 7.33 (6.93, 7.72) 7.40 (7.00, 7.79) 7.48 (7.08, 7.88) 6.90 6.76 (6.37, 7.15) 6.69 (6.30, 7.08) 6.83 (6.43, 7.24) <0.01 Observer scale Thickness 6.74 5.96 (5.43, 6.49) 5.39 (4.86, 5.92) 4.49 (3.94, 5.04) 6.74 6.31 (5.78, 6.84) 6.67 (6.14, 7.20) 6.35 (5.80, 6.90) 0.01 Observer scale Relief 6.66 6.73 (6.22, 7.24) 5.66 (5.15, 6.16) 4.96 (4.43, 5.48) 6.66 6.37 (5.86, 6.87) 6.37 (5.86, 6.87) 6.38 (5.86, 690) 0.01 Observer scale Pliability 7.17 6.31 (5.83, 6.79) 5.10 (4.62, 5.58) 3.97 (3.47, 4.47) 7.17 6.60 (6.12, 7.08) 6.88 (6.40, 7.36) 7.01 (6.51, 7.51) <0.01 Observer scale Surface 7.06 6.91 (6.54, 7.28) 6.91 (6.54, 7.28) 6.46 (6.08, 6.83) 7.06 7.07 (6.70, 7.44) 7.07 (6.70, 7.44) 6.66 (6.28, 7.03) 0.30 Observer scale Overall opinion 6.93 6.64 (6.34, 6.94) 6.00 (5.70, 6.30) 5.45 (5.14, 5.76) 6.93 6.50 (6.20, 6.80) 6.78 (6.48, 7.08) 6.76 (6.45, 7.07) <0.01 Patient scale Pain 3.76 1.85 (1.32, 2.60) 2.20 (1.56, 3.08) 2.77 (1.96, 3.92) 3.76 1.92 (1.36, 2.69) 2.29 (1.63, 3.21) 2.42 (1.71, 3.43) 0.79 Patient scale Itch 7.44 4.39 (2.29, 5.49) 4.54 (3.44, 5.64) 4.65 (3.52, 5.79) 7.44 4.68 (3.58, 5.78) 4.97 (3.87, 6.07) 5.53 (4.40, 6.67) 0.04 Patient scale Color 9.20 7.41 (6.18, 8.64) 7.62 (6.39, 8.85) 7.21 (5.96, 8.46) 9.20 6.55 (5.32, 7.78) 7.20 (5.96, 8.43) 7.48 (6.23, 8.73) 0.43 Patient scale Stiffness 8.57 7.02 (5.96, 8.07) 7.02 (5.96, 8.07) 6.34 (5.27, 7.42) 8.57 6.36 (5.31, 7.41) 7.50 (6.45, 8.55) 7.56 (6.49, 8.63) 0.18 Patient scale Thickness 8.90 7.27 (6.22, 8.32) 6.98 (5.93, 8.03) 6.18 (5.11, 7.25) 8.90 7.55 (6.50, 8.60) 7.55 (6.50, 8.60) 7.80 (6.73, 8.87) 0.01 Patient scale Irregularity 8.88 7.38 (6.44, 8.32) 7.09 (6.15, 8.03) 6.33 (5.36, 7.29) 8.88 7.38 (6.44, 8.32) 7.52 (6.58, 8.46) 8.15 (7.18, 9.11) 0.06 Patient scale Overall opinion 9.02 7.88 (7.05, 8.71) 7.66 (6.83, 8.50) 6.72 (5.86, 7.57) 9.02 7.95 (7.12, 8.78) 8.16 (7.33, 9.00) 8.12 (7.27, 8.98) 0.01
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