Vazula Bekkers

5. Needle-free electronically-controlled jet injector treatment with bleomycin is efficacious and well-tolerated in patients with severe keloids: results of a randomized, double-blind, placebo-controlled trial. 140 REFERENCES 1. Brown BC, McKenna SP, Siddhi K, McGrouther DA, Bayat A. The hidden cost of skin scars: quality of life after skin scarring. J Plast Reconstr Aesthet Surg 2008; 61: 104958. 2. Brown BC, Moss TP, McGrouther DA, Bayat A. Skin scar preconceptions must be challenged: importance of self-perception in skin scarring. J Plast Reconstr Aesthet Surg 2010; 63: 1022-9. 3. Huang C, Wu Z, Du Y, Ogawa R. The Epidemiology of Keloids. In: Textbook on Scar Management: State of the Art Management and Emerging Technologies (Téot L, Mustoe TA, Middelkoop E, Gauglitz GG, eds). Cham: Springer International Publishing, 2020: 29-35. 4. Shim J, Oh SJ, Yeo E, Park JH, Bae JH, Kim SH, Lee D, Lee JH. Integrated Analysis of Single-Cell and Spatial Transcriptomics in Keloids: Highlights on Fibrovascular Interactions in Keloid Pathogenesis. J Invest Dermatol 2022; 142: 2128-39 e11. 5. Ogawa R. Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis. Int J Mol Sci 2017; 18. 6. Ogawa R, Arima J, Ono S, Hyakusoku H. CASE REPORT Total Management of a Severe Case of Systemic Keloids Associated With High Blood Pressure (Hypertension): Clinical Symptoms of Keloids May Be Aggravated by Hypertension. Eplasty 2013; 13: e25. 7. Aluko-olokun B, Olaitan AA, Ladeinde AL, Oginni FO. The facial keloid: a comparison of treatment outcome between intralesional steroid injection and excision combined with radiotherapy. European Journal of Plastic Surgery 2014; 37: 361-6. 8. Jeschke MG, Wood FM, Middelkoop E, Bayat A, Teot L, Ogawa R, Gauglitz GG. Scars. Nature Reviews Disease Primers 2023; 9: 64. 9. Mourad B, Elfar N, Elsheikh S. Spray versus intralesional cryotherapy for keloids. J Dermatolog Treat 2016; 27: 264-9. 10. Liu R, Xiao H, Wang R, Li W, Deng K, Cen Y, Xu X. Risk factors associated with the progression from keloids to severe keloids. Chin Med J (Engl) 2022; 135: 828-36. 11. Gold MH, McGuire M, Mustoe TA, Pusic A, Sachdev M, Waibel J, Murcia C, International Advisory Panel on Scar M. Updated international clinical

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