6. Needle-free electronically-controlled jet injector treatment with bleomycin and lidocaine is effective and welltolerated in patients with recalcitrant keloids. 166 Needle-assisted bleomycin N=15 EPI-assisted bleomycin N=15 Treatment-related pain (NRS) Median [Q1 – Q3] Median [Q1 – Q3] P-value Pilot treatment* 7.0 [5.5 – 9.0] 2.0 [1.5 – 2.5] < 0.001 Three EPI- assisted bleomycin treatments** 3.0 [2.0 – 4.0] Supplement 3. Treatment- related pain Needle: needle-syringe injections EPI: electronically-controlled pneumatic injector NRS: Numerical Rating Scale (range 0-10) *Intra-patient comparison of needle-assisted bleomycin and EPI-assisted bleomycin Supplement 4. Adverse effects *Adverse effect in patient with history of experiencing similar pre-existing symptoms. N (%) n=15 Minor adverse effects observed after treatment Hematoma Hyperpigmentation Minor inflammation in keloid* Scab formation Superficial necrosis Transient itching Transient pain or sensitivity 3 (20%) 6 (40%) 1 (6,7%) 2 (13,3%) 1 (6,7%) 2 (13,3%) 1 (6,7%)
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