8. General discussion 212 uses optical energy, which creates a liquid bubble in the EPI that drives a micro-jet to penetrate the epidermis and dermis. The benefits of this laser-induced NFI is the accurate injection of a small volume (0.0003 mL) into a precise depth in the dermis.33 Furthermore, injections can be administered at a high frequency and with minimal injection-related pain. We would welcome the development of handheld devices based on this mechanism, which eventually could also be used in a home-setting for patients. This could significantly alleviate waiting time for an already overcrowded outpatient clinic waiting list, and eventually may contribute to reducing the rising costs of healthcare in general. Moreover, with EPI-assisted drug delivery of chemotherapeutics a smoke evacuator is necessary to capture aerosols is needed. A smoke evacuator is not available in all settings, which complicates ease of use. For this reason, a strong droplet evacuator could be integrated in the EPI to directly capture all aerosols during injection. Lastly, patients especially in the pediatric population can experience the noise of the EPI as disturbing. To make this treatment as child-friendly as possible, we would suggest to develop an EPI that makes negligible noise.
RkJQdWJsaXNoZXIy MTk4NDMw